VSIG4 Protein (His tag)

Produktnummer ABIN7535358

Produktdetails

Target: VSIG4 (V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses VSIG4 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human VSIG4 Protein

Sequenz: RPILEVPESV TGPWKGDVNL PCTYDPLQGY TQVLVKWLVQ RGSDPVTIFL RDSSGDHIQQ AKYQGRLHVS HKVPGDVSLQ LSTLEMDDRS HYTCEVTWQT PDGNQVVRDK ITELRVQKLS VSKPTVTTGS GYGFTVPQGM RISLQCQARG SPPISYIWYK QQTNNQEPIK VATLSTLLFK PAVIADSGSY FCTAKGQVGS EQHSDIVKFV VKDSSKLLKT KTEAPTTMTY PLKATSTVKQ SWDWTTDMDG YLGETSAGPG KSLP

Spezifität: Arg20-Pro283

Reinheit: > 95 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: <0.1EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: VSIG4 (V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4))

Andere Bezeichnung: VSIG4 (VSIG4 Produkte)

Synonyme: DKFZp468O0322 Protein, CRIg Protein, Z39IG Protein, A530061A11 Protein, BC025105 Protein, V-set and immunoglobulin domain containing 4 Protein, VSIG4 Protein, Vsig4 Protein

Hintergrund:

Description: VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 28 amino acid precursor that contains a signal sequence, a V-type I g domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type I g domain of mouse VSIG4 shares 86 % and 8 % aa sequence identity with the V-type I g domains of rat and human VSIG4, respectively.

Name: CRIg,Z39IG,VSIG4,VSIG4,CRIg,Z39IG,VSIG4

Gen-ID: 11326

UniProt: Q9Y279-1