TFF1 Protein (pSer2) (His tag)

Produktnummer ABIN7536423

Produktdetails

Target: TFF1 (Trefoil Factor 1 (TFF1))

Protein-Typ: Recombinant

Proteineigenschaft: pSer2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses TFF1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human BCEI/PS2/TFF1 Protein

Sequenz: EAQTETCTVA PRERQNCGFP GVTPSQCANK GCCFDDTVRG VPWCFYPNTI DVPPEEECEF

Spezifität: Glu25-Phe84

Reinheit: > 97 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.001 EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Konzentration: 1.1 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: TFF1 (Trefoil Factor 1 (TFF1))

Andere Bezeichnung: BCEI//TFF1 (TFF1 Produkte)

Synonyme: BCEI Protein, D21S21 Protein, HP1.A Protein, HPS2 Protein, pNR-2 Protein, pS2 Protein, Bcei Protein, PS2 Protein, bcei Protein, d21s21 Protein, hp1.a Protein, hps2 Protein, p1 Protein, p1-a Protein, pnr-2 Protein, ps2 Protein, tff1 Protein, xP1 Protein, xp1-L Protein, xp1 Protein, TFF1 Protein, Ps2 Protein, trefoil factor 1 Protein, trefoil factor 1 S homeolog Protein, trefoil factor 1, gene 2 S homeolog Protein, TFF1 Protein, Tff1 Protein, tff1.S Protein, tff1.2.S Protein, LOC100358238 Protein

Hintergrund:

Description: Trefoil Factor 1 (TFF1), also known as pS2, is one of three structurally related secreted proteins that contain trefoil domains. These domains adopt a three-leaved conformation held together by conserved intrachain disulfide bonds. TFF1 is an approximately 7 kDa peptide that plays an important role in epithelial regeneration and wound healing (1). Mature human TFF1 shares 67 % amino acid sequence identity with mouse and rat TFF1. It is expressed by goblet cells of the gastric and intestinal mucosa and by conjunctival goblet cells (2-5). TFF1 is a copper-binding protein that can form disulfide-linked homodimers, associate into disulfide-linked complexes with Gastrokine 2, and form non-covalent complexes with the mucin MUC5AC (4, 6-8). Copper enhances TFF1 homodimerization as well as its ability to promote epithelial cell motility, wound healing, and the colonization of H. pylori in stomach and colon epithelia (9, 10). TFF1 is down-regulated during the progression from gastritis to gastric dysplasia to gastric cancer, although it is up-regulated in breast and prostate cancers (11-13). TFF1 inhibits the formation of calcium oxalate crystals, and its excretion in the urine is reduced in patients with kidney stones (14).

Name: pS2, BCEI, HPS2, HP1.A, pNR-2, D21S21,TFF1

Gen-ID: 7031

UniProt: P04155

Pathways: EGFR Signaling Pathway