ROBO4 Protein (Fc Tag,His tag)

Produktnummer ABIN7535301

Produktdetails

Target: ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (ROBO4))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ROBO4 Protein ist gelabelt mit Fc Tag,His tag.

Verwendungszweck: Recombinant Human ROBO4 Protein

Sequenz: QDSPPQILVH PQDQLFQGPG PARMSCQASG QPPPTIRWLL NGQPLSMVPP DPHHLLPDGT LLLLQPPARG HAHDGQALST DLGVYTCEAS NRLGTAVSRG ARLSVAVLRE DFQIQPRDMV AVVGEQFTLE CGPPWGHPEP TVSWWKDGKP LALQPGRHTV SGGSLLMARA EKSDEGTYMC VATNSAGHRE SRAARVSIQE PQDYTEPVEL LAVRIQLENV TLLNPDPAEG PKPRPAVWLS WKVSGPAAPA QSYTALFRTQ TAPGGQGAPW AEELLAGWQS AELGGLHWGQ DYEFKVRPSS GRARGPDSNV LLLRLPEKVP SAPPQEVTLK PGNGTVFVSW VPPPAENHNG IIRGYQVWSL GNTSLPPANW TVVGEQTQLE IATHMPGSYC VQVAAVTGAG AGEPSRPVCL LLEQAMERAT QEPSEHGPWT LEQLRATLKR

Spezifität: Gln28-Arg467

Reinheit: > 95 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: <0.1EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (ROBO4))

Andere Bezeichnung: ROBO4 (ROBO4 Produkte)

Synonyme: ECSM4 Protein, MRB Protein, 1200012D01Rik Protein, AI593217 Protein, sc:d0823 Protein, wu:fa16f09 Protein, roundabout guidance receptor 4 Protein, roundabout, axon guidance receptor, homolog 4 (Drosophila) Protein, ROBO4 Protein, Robo4 Protein, robo4 Protein

Hintergrund:

Description: Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.

Name: ROBO4,ECSM4,MRB

Gen-ID: 54538

UniProt: Q8WZ75