GFRA2 Protein (His tag)

Produktnummer ABIN7534248

Produktdetails

Target: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses GFRA2 Protein ist gelabelt mit His tag.

Verwendungszweck: Active Recombinant Human GDNFR-alpha-2/GFRA2 Protein

Sequenz: SPSSLQGPEL HGWRPPVDCV RANELCAAES NCSSRYRTLR QCLAGRDRNT MLANKECQAA LEVLQESPLY DCRCKRGMKK ELQCLQIYWS IHLGLTEGEE FYEASPYEPV TSRLSDIFRL ASIFSGTGAD PVVSAKSNHC LDAAKACNLN DNCKKLRSSY ISICNREISP TERCNRRKCH KALRQFFDRV PSEYTYRMLF CSCQDQACAE RRRQTILPSC SYEDKEKPNC LDLRGVCRTD HLCRSRLADF HANCRASYQT VTSCPADNYQ ACLGSYAGMI GFDMTPNYVD SSPTGIVVSP WCSCRGSGNM EEECEKFLRD FTENPCLRNA IQAFGNGTDV NVSPKGPSFQ ATQAPRVEKT PSLPDDLSDS TSLGTSVITT CTSVQEQGLK ANNSKELSMC FTELTTNIIP GSNKVIKPNS

Spezifität: Ser22-Ser441

Reinheit: > 95 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human Neurturin at 5 μg/mL (100 μL/well) can bind recombinant Human GFRA2, the EC₅₀ of Human GFRA2 is 1.82 μg/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Antigendetails

Target: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Andere Bezeichnung: GDNFR-alpha-2/GFRA2 (GFRA2 Produkte)

Synonyme: GDNFRB Protein, NRTNR-ALPHA Protein, NTNRA Protein, RETL2 Protein, TRNR2 Protein, Retl2 Protein, NTNRALPHA Protein, ntnra Protein, retl2 Protein, trnr2 Protein, gdnfrb Protein, nrtnr-alpha Protein, gfra2 Protein, GDNF family receptor alpha 2 Protein, glial cell line derived neurotrophic factor family receptor alpha 2 Protein, GDNF family receptor alpha 2a Protein, GFRA2 Protein, Gfra2 Protein, gfra2 Protein, gfra2a Protein

Hintergrund:

Description: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases.

Name: GFRA2,GDNFRB,NRTNR-ALPHA,NTNRA,RETL2,TRNR2

Gen-ID: 2675

UniProt: O00451