DNER Protein (Fc Tag,His tag)

Produktnummer ABIN7534322

Produktdetails

Target: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses DNER Protein ist gelabelt mit Fc Tag,His tag.

Verwendungszweck: Recombinant Human DNER Protein

Sequenz: RGSSLANPVP AAPLSAPGPC AAQPCRNGGV CTSRPEPDPQ HPAPAGEPGY SCTCPAGISG ANCQLVADPC ASNPCHHGNC SSSSSSSSDG YLCICNEGYE GPNCEQALPS LPATGWTESM APRQLQPVPA TQEPDKILPR SQATVTLPTW QPKTGQKVVE MKWDQVEVIP DIACGNASSN SSAGGRLVSF EVPQNTSVKI RQDATASLIL LWKVTATGFQ QCSLIDGRSV TPLQASGGLV LLEEMLALGN NHFIGFVNDS VTKSIVALRL TLVVKVSTCV PGESHANDLE CSGKGKCTTK PSEATFSCTC EEQYVGTFCE EYDACQRKPC QNNASCIDAN EKQDGSNFTC VCLPGYTGEL CQSKIDYCIL DPCRNGATCI SSLSGFTCQC PEGYFGSACE EKVDPCASSP CQNNGTCYVD GVHFTCNCSP GFTGPTCAQL IDFCALSPCA HGTCRSVGTS YKCLCDPGYH GLYCEEEYNE CLSAPCLNAA TCRDLVNGYE CVCLAEYKGT HCELYKDPCA NVSCLNGATC DSDGLNGTCI CAPGFTGEEC DIDINECDSN PCHHGGSCLD QPNGYNCHCP HGWVGANCEI HLQWKSGHMA ESLTNMPRH

Spezifität: Arg29-His637

Reinheit: > 97 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.01 EU/μg of the protein by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Antigendetails

Target: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Andere Bezeichnung: DNER (DNER Produkte)

Synonyme: UNQ26 Protein, bet Protein, A930026D19Rik Protein, BET Protein, Bret Protein, delta/notch like EGF repeat containing Protein, delta and Notch-like epidermal growth factor-related receptor Protein, delta/notch-like EGF repeat containing Protein, DNER Protein, LOC540552 Protein, Dner Protein

Hintergrund:

Description: DNER (Delta/Notch-like EGF-related receptor), also known as BET (brain-specific EGF-like transmembrane protein), is a type I transmembrane glycoprotein of the Notch/Delta family . In the mouse, DNER has been detected as 90, 120 and 150 kDa forms which are probably variably glycosylated .Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.DNER associates with protein tyrosine phosphatase zeta (PTP zeta ), which is the receptor of pleiotrophin (PTN). PTP zeta -PTN-DNER signaling has been implicated in the regulation of neuritogenesis. Expression of DNER in glioblastoma stem-like cells inhibits formation of neurospheres in vitro, while in vivo it induces differentiation and inhibits growth of xenografts, thus acting as a tumor suppressor.

Name: DNER,UNQ26,bet

Gen-ID: 92737

UniProt: Q8NFT8

Pathways: Skeletal Muscle Fiber Development