VEGF121 Protein (AA 1-147) (His tag)

Produktnummer ABIN7505598

Produktdetails

Target: VEGF121 (Vascular Endothelial Cell Growth Factor 121 (VEGF121))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-147

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses VEGF121 Protein ist gelabelt mit His tag.

Sequenz: Met1-Arg147

Produktmerkmale: A DNA sequence encoding theHuman VEGF121 protein (P15692-9) (Met1-Arg147) was expressed with a C-His.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: VEGF121 (Vascular Endothelial Cell Growth Factor 121 (VEGF121))

Andere Bezeichnung: VEGF121 (VEGF121 Produkte)

Hintergrund:

Background: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform ', ' binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor.

Synonym: VEGF-A,Vascular permeability factor,VPF,VEGFA

Molekulargewicht: 17.2 kDa