DNMT1 Protein (AA 950-1142) (His tag)

Produktnummer ABIN7505473

Produktdetails

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 950-1142

Spezies: Ratte

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses DNMT1 Protein ist gelabelt mit His tag.

Sequenz: Phe950-Pro1142

Produktmerkmale: A DNA sequence encoding the Rat DNMT1 (Q9Z330-1) (Phe950-Pro1142) was expressed with a polyhistidine tag at the N-terminus.

Reinheit: >80 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Andere Bezeichnung: DNMT1 (DNMT1 Produkte)

Synonyme: cb1075 Protein, cb983 Protein, dmnt1 Protein, fb05h01 Protein, mta Protein, wu:fb05h01 Protein, ADCADN Protein, AIM Protein, CXXC9 Protein, DNMT Protein, HSN1E Protein, MCMT Protein, DDM2 Protein, DECREASED DNA METHYLATION 2 Protein, DMT01 Protein, DMT1 Protein, DNA METHYLTRANSFERASE Protein, DNA METHYLTRANSFERASE 01 Protein, DNA METHYLTRANSFERASE 1 Protein, MET2 Protein, METHYLTRANSFERASE 2 Protein, METHYLTRANSFERASE I Protein, METI Protein, methyltransferase 1 Protein, Cxxc9 Protein, Dnmt Protein, Dnmt1o Protein, MTase Protein, Met-1 Protein, Met1 Protein, MommeD2 Protein, m.MmuI Protein, DNA methyltransferase 1 Protein, DNA (cytosine-5-)-methyltransferase 1 Protein, methyltransferase 1 Protein, DNA methyltransferase (cytosine-5) 1 Protein, DNMT1 Protein, dnmt1 Protein, Dnmt1 Protein, MET1 Protein

Hintergrund:

Background: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth.

Synonym: DNA (cytosine-5)-methyltransferase 1,Dnmt1,Met-1,DNA methyltransferase MmuI,DNA MTase MmuI,M.MmuI,MCMT,Dnmt, Met1, Uim

Molekulargewicht: 22.01 kDa

UniProt: Q9Z330

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion