Ki-67 Protein (AA 1001-1112) (His tag)

Produktnummer ABIN7505015

Produktdetails

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1001-1112

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Ki-67 Protein ist gelabelt mit His tag.

Sequenz: Lys1001-Pro1112

Produktmerkmale: A DNA sequence encoding theHuman KI67 protein (P46013) (Lys1001-Pro1112) was expressed with a N-His.

Reinheit: >85 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Andere Bezeichnung: KI67 (MKI67 Produkte)

Synonyme: MKI67 Protein, kia Protein, mki67 Protein, MGC132156 Protein, D630048A14Rik Protein, Ki-67 Protein, Ki67 Protein, KIA Protein, MIB-1 Protein, marker of proliferation Ki-67 Protein, marker of proliferation Ki-67 L homeolog Protein, marker of proliferation Ki-67 S homeolog Protein, antigen identified by monoclonal antibody Ki 67 Protein, antigen identified by monoclonal antibody Ki-67 Protein, nucleolar protein interacting with the FHA domain of MKI67 Protein, MKI67 Protein, mki67 Protein, mki67.L Protein, mki67.S Protein, Mki67 Protein, NIFK Protein

Hintergrund:

Background: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly.Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface.Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility.Binds DNA, with a preference for supercoiled DNA and AT-rich DNA.Does not contribute to the internal structure of mitotic chromosomes.May play a role in chromatin organization.It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Synonym: Antigen identified by monoclonal antibody Ki-67,Antigen KI-67,Antigen Ki67

Molekulargewicht: 12.4 kDa

UniProt: P46013

Pathways: Glycosaminoglycan Metabolic Process