GAPDH Protein (AA 1-333) (His tag)

Produktnummer ABIN7504953

Produktdetails

Target: GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-333

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses GAPDH Protein ist gelabelt mit His tag.

Sequenz: Met1-Glu333

Produktmerkmale: A DNA sequence encoding the Human GAPDH (P04406) (1M-333E) was expressed with a polyhistidine tag at the N-terminus.

Reinheit: >90 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Kommentare:

used as Immunogen for (ABIN6999908, ABIN7234256, ABIN7234257 and ABIN7234258)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH))

Andere Bezeichnung: GAPDH (GAPDH Produkte)

Synonyme: G3PD Protein, GAPD Protein, Gapd Protein, BEST:GH12586 Protein, CG12055 Protein, Dmel\\CG12055 Protein, GA3PDH Protein, GADPH Protein, GAP Protein, GAPDH Protein, GAPDH I Protein, GAPDH-1 Protein, GAPDH1 Protein, GAPDHI Protein, Gapdh Protein, Gapdh-1 Protein, Gapdh43E Protein, gadph Protein, gapdh Protein, gapdh-1 Protein, gh12586 Protein, cb609 Protein, gapd Protein, mg:bb02e05 Protein, wu:fb33a10 Protein, wu:ft80f05 Protein, KNC-NDS6 Protein, g3pd Protein, G3PDH Protein, glyceraldehyde-3-phosphate dehydrogenase Protein, Glyceraldehyde 3 phosphate dehydrogenase 1 Protein, glyceraldehyde-3-phosphate dehydrogenase S homeolog Protein, glyceraldehyde-3-phosphate dehydrogenase, type I Protein, olfactory receptor 8K3 Protein, GAPDH Protein, Gapdh Protein, Gapdh1 Protein, gapdh Protein, gapdh.S Protein, gapDH Protein, LOC100404960 Protein, LOC614985 Protein

Hintergrund:

Background: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Synonym: Aging associated gene 9 protein,Epididymis secretory sperm binding protein Li 162eP,G3P,G3PD,G3PDH,GAPD,GAPDH,Glyceraldehyde 3 phosphate dehydrogenase,Glyceraldehyde-3-phosphate dehydrogenase,HEL S 162eP,Peptidyl-cysteine S-nitrosylase GAPDH

Molekulargewicht: 37.1 kDa

UniProt: P04406