Merlin Protein (AA 1-595) (His tag)

Produktnummer ABIN7504952

Produktdetails

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-595

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Merlin Protein ist gelabelt mit His tag.

Sequenz: Met1-Leu595

Produktmerkmale: A DNA sequence encoding the Human Merlin/NF2 (P35240-1) (1M-595L) was expressed with a polyhistidine tag at the N-terminus.

Reinheit: >90 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Kommentare:

used as Immunogen for (ABIN6999888, ABIN7234196, ABIN7234197 and ABIN7234198)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4., 5 % trehalose, 5 % mannitol, 0.01 % tween-80.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Andere Bezeichnung: Merlin (NF2 Produkte)

Synonyme: ACN Protein, BANF Protein, SCH Protein, NF2 Protein, merlin Protein, zgc:194620 Protein, zgc:194631 Protein, NF2a Protein, nf2 Protein, neurofibromin 2 Protein, neurofibromin 2a (merlin) Protein, neurofibromin 2b (merlin) Protein, neurofibromin 2 (merlin) S homeolog Protein, NF2 Protein, Nf2 Protein, nf2a Protein, nf2b Protein, nf2.S Protein

Hintergrund:

Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Synonym: CAN, BANF, Bilateral acoustic neuroma, MERL_HUMAN, Merlin, Moesin ezrin radixin like protein, Moesin ezrin radizin like, Moesin-ezrin-radixin-like, Neurofibromatosis 2, Neurofibromatosis type 2, Neurofibromatosis2, NF 2, SCH, Schwannomerlin

Molekulargewicht: 69.7 kDa

Pathways: Cell-Cell Junction Organization