TDGF1 Protein (AA 31-172) (His tag)

Produktnummer ABIN7504538

Produktdetails

Target: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 31-172

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses TDGF1 Protein ist gelabelt mit His tag.

Verwendungszweck: Human TDGF1/Cripto Protein

Sequenz: Leu31-Thr172

Produktmerkmale: Recombinant Human TDGF1/Cripto Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu31-Thr172.

Reinheit: > 95 % as determined by Tris-Bis PAGE

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Andere Bezeichnung: TDGF1 (TDGF1 Produkte)

Synonyme: CR Protein, CRGF Protein, CRIPTO Protein, CR1 Protein, cripto Protein, cb85 Protein, tdgf1 Protein, wu:fe01d04 Protein, zgc:109829 Protein, Cripto-1 Protein, cr1 Protein, cr1a Protein, frl-1 Protein, frl1 Protein, xcr1 Protein, TDGF1 Protein, tdgf3 Protein, cripto-3 Protein, teratocarcinoma-derived growth factor 1 Protein, teratocarcinoma-derived growth factor 1, member 3 L homeolog Protein, teratocarcinoma-derived growth factor 1, member 1 Protein, TDGF1 Protein, Tdgf1 Protein, tdgf1 Protein, tdgf1.3.L Protein, tdgf1.1 Protein

Hintergrund: TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.

Molekulargewicht: 16.92 kDa. Due to glycosylation, the protein migrates to 23-30 kDa based on Tris-Bis PAGE result.

UniProt: P13385

Pathways: EGFR Signaling Pathway