Recombinant Human HLA-A*03:01 & B2M & KRAS G12V (VVGAVGVGK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-TerminusIt contains Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVGAVGVGK peptide.
Reinheit
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Supplied as 0.22 μm filtered solution in PBS ( pH 7.4).
Lagerung
-80 °C
Informationen zur Lagerung
Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Haltbarkeit
12 months
Target
HLA-A*03:01
Hintergrund
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Molekulargewicht
50.09 kDa. Due to glycosylation, the protein migrates to 52-65 kDa based on Tris-Bis PAGE result.