ADAM9 Protein (His tag)

Produktnummer ABIN7482563

Produktdetails

Target: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ADAM9 Protein ist gelabelt mit His tag.

Verwendungszweck: Mouse ADAM9 Protein, His Tag (active enzyme, MALS verified)

Sequenz: Ala 206 - Asp 697

Produktmerkmale: Mouse ADAM9, His Tag is expressed from human 293 cells (HEK293). It contains AA Ala 206 - Asp 697 (Accession # Q61072).

Reinheit: 95 %

Endotoxin-Niveau: 1.0 EU per μg

Güteklasse: MALS verified

Anwendungsinformationen

Kommentare:

This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 55.2 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 25 mM MES,150 mM NaCl, pH 6.0

Lagerung: -80 °C

Informationen zur Lagerung: -70°C

Antigendetails

Target: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Andere Bezeichnung: ADAM9 (ADAM9 Produkte)

Synonyme: CORD9 Protein, MCMP Protein, MDC9 Protein, Mltng Protein, AU020942 Protein, mKIAA0021 Protein, adam9-A Protein, cord9 Protein, mcmp Protein, mltng Protein, Adam9 Protein, zgc:101824 Protein, ADAM9 Protein, ADAM metallopeptidase domain 9 Protein, a disintegrin and metallopeptidase domain 9 (meltrin gamma) Protein, ADAM metallopeptidase domain 9 L homeolog Protein, ADAM9 Protein, Adam9 Protein, adam9.L Protein, adam9 Protein

Hintergrund: ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins. ADAM9 influences the developmental process, inflammation, and degenerative diseases.Recently, increasing evidence has shown that ADAM9 plays an important role in tumor biology. Overexpression of ADAM9 has been found in several cancer types and is correlated with tumoraggressiveness and poor prognosis. In addition, through either proteolytic or non-proteolytic pathways, ADAM9 promotes tumor progression, therapeutic resistance, and metastasis of cancers.Therefore, comprehensively understanding the mechanism of ADAM9 is crucial for the development of therapeutic anti-cancer strategies. In this review, we summarize the current understanding of ADAM9 in biological function, pathophysiological diseases, and various cancers. Recent advances in therapeutic strategies using ADAM9-related pathways are presented as well.

Molekulargewicht: 55.2 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin, SARS-CoV-2 Protein Interaktom