EGFRviii Protein (APC,His tag)

Produktnummer ABIN7482330

Produktdetails

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses EGFRviii Protein ist gelabelt mit APC,His tag.

Verwendungszweck: APC-Labeled Human EGFRvIII Protein, His TagStar Staining

Sequenz: Leu 25 - Ser 378

Produktmerkmale: APC-Labeled Human EGFRvIII, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 378 (Accession # NP_001333870.1).

Reinheit: 90 %

Endotoxin-Niveau: 1.0 EU per μg

Anwendungsinformationen

Kommentare:

This protein carries a polyhistidine tag at the C-terminus. (APC ,10xHis) The protein has a calculated MW of 53.0 kDa.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, 0.2 % BSA, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C, avoid light

Antigendetails

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Andere Bezeichnung: EGFRvIII (EGFRv3 Produkte)

Hintergrund: The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors. This tumor-specific antigen is ligand-independent, contains a constitutively active tyrosine kinase domain, and has been shown to be present in a number of human malignancies. EGFRvIII has been selected as a target for CAR-modified T-cell studies in recent years.

Molekulargewicht: 53.0 kDa