CMKLR1 Protein

Produktnummer ABIN7491613

Produktdetails

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Protein-Typ: Synthetic

Spezies: Human

Quelle: HEK-293 Cells

Verwendungszweck: Human CMKLR1 full length protein-synthetic nanodisc

Produktmerkmale: Full Length Transmembrane Proteins (synthetic Nanodisc)

Anwendungsinformationen

Applikationshinweise:

• Applications for VLPs:
• ELISA
• SPR affinity analysis
• Phage display screening
• Immunization
• Cell based assays
• CAR-T cell screening
• Protein cystal structure analysis

Kommentare:

Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Andere Bezeichnung: CMKLR1 (CMKLR1 Produkte)

Synonyme: CHEMERINR Protein, ChemR23 Protein, DEZ Protein, RVER1 Protein, Gpcr27 Protein, mcmklr1 Protein, si:ch211-240b21.3 Protein, CMLKR1 Protein, Cmklr-1 Protein, GPCR Protein, chemerin chemokine-like receptor 1 Protein, chemokine-like receptor 1 Protein, CMKLR1 Protein, Cmklr1 Protein, cmklr1 Protein

Hintergrund: CHEMERINR, ChemR23, DEZ, RVER1
Description: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).[UniProtKB/Swiss-Prot Function]

Molekulargewicht: The human full length CMKLR1 protein has a MW of 42.1 kDa

UniProt: Q99788