RHOB Protein (Fc Tag)

Produktnummer ABIN7491409

Produktdetails

Target: RHOB (Ras Homolog Gene Family, Member B (RHOB))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses RHOB Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human RHOB Protein with C-terminal human Fc tag

Spezifität: RHOB (Met1-Gly188) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: RHOB (Ras Homolog Gene Family, Member B (RHOB))

Andere Bezeichnung: RHOB (RHOB Produkte)

Synonyme: ARH6 Protein, ARHB Protein, MST081 Protein, MSTP081 Protein, RHOH6 Protein, AA017882 Protein, Arh6 Protein, Arhb Protein, RHO Protein, arha Protein, rhoa Protein, wu:fj42e08 Protein, zgc:92206 Protein, rhob Protein, xrhob Protein, ras homolog family member B Protein, ras homolog gene family, member Ab Protein, ras homolog family member B S homeolog Protein, RHOB Protein, Rhob Protein, rhoab Protein, rhob.S Protein

Hintergrund: ARH6, ARHB, MST081, MSTP081, RHOH6Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.[UniProtKB/Swiss-Prot Function]

Molekulargewicht: predicted molecular mass of 47.4 kDa after removal of the signal peptide. The apparent molecular mass of RHOB-hFc is 35-55 kDa due to glycosylation.

UniProt: P62745