Acetylcholinesterase Protein (AChE) (His tag)

Produktnummer ABIN7491383

Produktdetails

Target: Acetylcholinesterase (AChE)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Acetylcholinesterase Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human ACHE Protein with C-terminal 6xHis tag

Spezifität: ACHE (Glu32-Leu614) 6xHis tag

Produktmerkmale: Extracellular Domain Protein

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: Acetylcholinesterase (AChE)

Andere Bezeichnung: ACHE (AChE Produkte)

Synonyme: ACEE Protein, ARACHE Protein, N-ACHE Protein, YT Protein, Ache Protein, GB14873 Protein, zgc:92550 Protein, ACE Protein, Dsim\\GD20515 Protein, GD20515 Protein, dsim_GLEANR_4292 Protein, ache Protein, mE1a Protein, mE1b Protein, mE1c Protein, mE1c-long Protein, mE1d Protein, mE1d' Protein, mE1e Protein, arache Protein, n-ache Protein, acetylcholinesterase (Cartwright blood group) Protein, acetylcholinesterase 2 Protein, acetylcholinesterase Protein, Acetylcholine esterase Protein, acetylcholinesterase (Cartwright blood group) L homeolog Protein, collagen type I alpha 2 chain Protein, ACHE Protein, AChE-2 Protein, Ache Protein, ache Protein, Dsim\Ace Protein, ache.L Protein, COL1A2 Protein, ACE-1 Protein

Hintergrund: ACEE, ARACHE, N-ACHE, YTAcetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion[provided by RefSeq, Sep 2019]

Molekulargewicht: predicted molecular mass of 65.4 kDa after removal of the signal peptide. The apparent molecular mass of ACHE-His is 55-70 kDa due to glycosylation.

UniProt: P22303

Pathways: Skeletal Muscle Fiber Development