Crystallography grade
TMEM106B
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ELISA, Crys, SDS, WB
Crystallography grade
TMEM106B
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ELISA, Crys, SDS, WB
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
Buffer
Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
Lagerung
-20 °C,-80 °C
Informationen zur Lagerung
-20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
2310036D22Rik Protein, 5830455K21Rik Protein, 6430519M21Rik Protein, AI428776 Protein, AI661344 Protein, LRRGT00101 Protein, MGC81788 Protein, tmem106b Protein, zgc:114147 Protein, zgc:64013 Protein, transmembrane protein 106B Protein, transmembrane protein 106B S homeolog Protein, transmembrane protein 106Bb Protein, transmembrane protein 106b Protein, transmembrane protein 106Ba Protein, TMEM106B Protein, Tmem106b Protein, tmem106b.S Protein, tmem106b Protein, tmem106bb Protein, Tsp_02056 Protein, Tsp_01553 Protein, t106b Protein, tmem106ba Protein
Hintergrund
TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013, Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).
Molekulargewicht
44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Tris-Bis PAGE result.