SIGLEC5 Protein (AA 17-434) (Fc Tag)

Produktnummer ABIN7275589

Produktdetails

Target: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Protein-Typ: Recombinant

Proteineigenschaft: AA 17-434

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SIGLEC5 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Human Siglec-5/CD170 Protein

Sequenz: Glu17-Thr434

Produktmerkmale: Recombinant Human Siglec-5/CD170 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu17-Thr434.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Andere Bezeichnung: Siglec-5 (SIGLEC5 Produkte)

Synonyme: CD170 Protein, CD33L2 Protein, OB-BP2 Protein, OBBP2 Protein, SIGLEC-5 Protein, sialic acid binding Ig like lectin 5 Protein, sialic acid-binding Ig-like lectin 5 Protein, sialic acid binding Ig-like lectin 5 Protein, SIGLEC5 Protein, LOC100597560 Protein, Siglec5 Protein

Hintergrund: Interactions between endothelial selectins and the leukocyte counter-receptor PSGL1 mediates leukocyte recruitment to inflammation sites. PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures. Binding assays using soluble Siglec-5 variants (sSiglec-5/C4BP and sSiglec-5/Fc) revealed a dose- and calcium-dependent binding to PSGL1.

Molekulargewicht: 73.1 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.

UniProt: O15389