SEMA7A Protein (AA 45-648) (His tag)

Produktnummer ABIN7275564

Produktdetails

Target: SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))

Protein-Typ: Recombinant

Proteineigenschaft: AA 45-648

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SEMA7A Protein ist gelabelt mit His tag.

Verwendungszweck: Human SEMA7A Protein

Sequenz: Gln45-Ala648

Produktmerkmale: Recombinant Human SEMA7A Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln45-Ala648.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))

Andere Bezeichnung: SEMA7A (SEMA7A Produkte)

Synonyme: 2900057C09Rik Protein, CDw108 Protein, H-Sema-L Protein, M-Sema-L Protein, Semal Protein, CD108 Protein, H-SEMA-K1 Protein, JMH Protein, SEMAK1 Protein, SEMAL Protein, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A Protein, semaphorin 7A (John Milton Hagen blood group) Protein, Sema7a Protein, SEMA7A Protein

Hintergrund: Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic rats, which may be related to neuroinflammation. Sema7A promotes the inflammatory cytokines TNF-α and IL-6 as well as the growth of mossy fibers through the ERK pathway, suggesting that Sema7A may promote seizures by increasing neuroinflammation and activating pathological neural circuits. Sema7A plays a critical role in epilepsy and could be a potential therapeutic target for this neurological disorder.

Molekulargewicht: 69.5 kDa. Due to glycosylation, the protein migrates to 70-75 kDa based on Tris-Bis PAGE result.

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size