Factor XI Protein (AA 19-625) (His tag)

Produktnummer ABIN7274693

Produktdetails

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Protein-Typ: Recombinant

Proteineigenschaft: AA 19-625

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Factor XI Protein ist gelabelt mit His tag.

Verwendungszweck: Human Coagulation factor XI Protein

Sequenz: Glu19-Val625

Produktmerkmale: Recombinant Human Coagulation factor XI Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu19-Val625.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in 25 mM HEPES, 150 mM NaCl ( pH 7.5). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Andere Bezeichnung: Coagulation factor XI (F11 Produkte)

Synonyme: FXI Protein, 1600027G01Rik Protein, AI503996 Protein, Cf11 Protein, LRRGT00086 Protein, coagulation factor XI Protein, F11 Protein, CpipJ_CPIJ000593 Protein, CpipJ_CPIJ001060 Protein, CpipJ_CPIJ002752 Protein, CpipJ_CPIJ003631 Protein, CpipJ_CPIJ004041 Protein, CpipJ_CPIJ004093 Protein

Hintergrund: Coagulation factor (F)XI has been described as a component of the early phase of the contact pathway of blood coagulation, acting downstream of factor XII.In contrast to its mild hemostatic activities, FXI is known to play a significant role in thrombosis, as it is a demonstrated independent risk factor for deep vein thrombosis, ischemic stroke, and myocardial infarction. A better understanding of the varied and complex role of FXI in both thrombosis and hemostasis will help to allow better prediction of bleeding risk in FXI-deficient patients and also informing the development of targeted agents to inhibit the thrombotic activities of FXI while preserving hemostasis.

Molekulargewicht: 69.1 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.