FOLR1 Protein (Biotin,His-Avi Tag)

Produktnummer ABIN7319830

Produktdetails

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses FOLR1 Protein ist gelabelt mit Biotin,His-Avi Tag.

Verwendungszweck: Recombinant Human Folate Receptor alpha/FOLR1 (C-6His-Avi) Biotinylated

Sequenz: Arg25-Ser234

Produktmerkmale: Biotinylated Recombinant Human Folate Receptor Alpha is produced by our Mammalian expression system and the target gene encoding Arg25-Ser234 is expressed with a 6His, Avi tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Kommentare:

35-40 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Andere Bezeichnung: FOLR1 (FOLR1 Produkte)

Synonyme: FBP Protein, FOLR Protein, fbp Protein, folr Protein, folr1 Protein, FBP1 Protein, Folbp-1 Protein, Folbp1 Protein, Fbp1 Protein, FOLR1 Protein, Folr1 Protein, folate receptor 1 Protein, folate receptor 1 (adult) Protein, folate receptor 1 (adult) L homeolog Protein, zgc:165502 Protein, Folate receptor alpha Protein, folate receptor alpha Protein, FOLR1 Protein, folr1 Protein, folr1.L Protein, zgc:165502 Protein, Folr1 Protein, LOC100066084 Protein, LOC100725439 Protein

Hintergrund:

Background: Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH . Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

Synonym: Folate receptor alpha, FR-alpha, Adult folate-binding protein, FBP, Folate receptor 1, Folate receptor, Ovarian tumor-associated antigen MOv18, FOLR1

Molekulargewicht: 27.5 kDa

UniProt: P15328

Pathways: Dicarboxylic Acid Transport