XPNPEP2 Protein (His tag)

Produktnummer ABIN7198721

Produktdetails

Target: XPNPEP2 (X-Prolyl Aminopeptidase (Aminopeptidase P) 2, Membrane-Bound (XPNPEP2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses XPNPEP2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human XPNPEP2 Protein (His Tag)(Active)

Sequenz: Met 1-Ala 650

Produktmerkmale: A DNA sequence encoding the human XPNPEP2 (O43895) (Met 1-Ala 650) without the pro peptide was expressed, with a polyhistidine tag at the C-terminus.

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave the fluorogenic peptide substrate, H-Lys(2-Aminobenzoyl)Pro-Pro-pNitroanilide(K(Abz)PP-pNA).The specific activity is > 300 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: XPNPEP2 (X-Prolyl Aminopeptidase (Aminopeptidase P) 2, Membrane-Bound (XPNPEP2))

Andere Bezeichnung: XPNPEP2 (XPNPEP2 Produkte)

Synonyme: APP2 Protein, 9030008G12Rik Protein, mAPP Protein, XPNPEP2 Protein, zK61O11.1 Protein, zgc:63528 Protein, X-prolyl aminopeptidase 2 Protein, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound Protein, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound L homeolog Protein, XPNPEP2 Protein, Xpnpep2 Protein, xpnpep2.L Protein, xpnpep2 Protein

Hintergrund:

Background: Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds; which are common to several collagen degradation products; neuropeptides; vasoactive peptides; and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2; the X-linked gene that encodes membranous aminopeptidase P (APP); has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution to endothelia and brush border epithelia. APP and XPNPEP2 contain homologous blocks of sequence common to members of the "pita bread-fold" protein family; of which Escherichia coli methionine aminopeptidase is the prototype. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation; suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).

Synonym: Xaa-Pro Aminopeptidase 2; Aminoacylproline Aminopeptidase; Membrane-Bound Aminopeptidase P; Membrane-Bound APP; Membrane-Bound AmP; mAmP; X-Pro Aminopeptidase 2; XPNPEP2

Molekulargewicht: 72 kDa

UniProt: O43895