WDYHV1 Protein (GST tag)

Produktnummer ABIN7318958

Produktdetails

Target: WDYHV1 (WDYHV Motif Containing 1 (WDYHV1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses WDYHV1 Protein ist gelabelt mit GST tag.

Verwendungszweck: Recombinant Human WDYHV1/NTAQ1 Protein (GST Tag)

Sequenz: Met 1-Cys205

Produktmerkmale: Recombinant Human Protein N-terminal glutamine amidohydrolase is produced by our E.coli expression system and the target gene encoding Met1-Cys205 is expressed with a GST tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS,100 mM GSH,1 % TritonX-100,15 % Glycerol, pH 7.4.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: WDYHV1 (WDYHV Motif Containing 1 (WDYHV1))

Andere Bezeichnung: WDYHV1/NTAQ1 (WDYHV1 Produkte)

Synonyme: ntaq1 Protein, C8orf32 Protein, 2410187C16Rik Protein, AU014961 Protein, AW550036 Protein, Ntaq1 Protein, RGD1311362 Protein, C14H8orf32 Protein, si:rp71-45k5.3 Protein, WDYHV motif containing 1 Protein, WDYHV motif containing 1 S homeolog Protein, WDYHV1 Protein, wdyhv1.S Protein, wdyhv1 Protein, Wdyhv1 Protein

Hintergrund:

Background: Human protein N-terminal glutamine amidohydrolase (WDYHV1) is an enzyme that in humans is encoded by the WDYHV1 gene, belongs to the NTAQ1 family.WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, which is an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. However,it does not act on substrates with internal or C-terminal glutamine andnon-glutamine residues in any position. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.

Synonym: Protein N-terminal glutamine amidohydrolase,WDYHV1,Protein NH2-terminal glutamine deamidase,N-terminal Gln amidase,Nt(Q)-amidase,C8orf32, NTAQ1

Molekulargewicht: 49.8 kDa

UniProt: Q96HA8