B4GALT1 Protein (His tag)

Produktnummer ABIN7319810

Produktdetails

Target: B4GALT1 (UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses B4GALT1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human B4GALT1 (C-6His)

Sequenz: Gly44-Ser398(Tyr285Leu)

Produktmerkmale: Recombinant Human Beta-1,4-galactosyltransferase 1 is produced by our Mammalian expression system and the target gene encoding Gly44-Ser398(Tyr285Leu) is expressed with a 6His tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: B4GALT1 (UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1))

Andere Bezeichnung: B4GALT1 (B4GALT1 Produkte)

Synonyme: B4GAL-T1 Protein, CDG2D Protein, GGTB2 Protein, GT1 Protein, GTB Protein, beta4Gal-T1 Protein, B-1,4-GalT Protein, B-1,4-GalT1 Protein, GalT Protein, Ggtb Protein, Ggtb2 Protein, b4Gal-T1 Protein, beta-1,4-GalT Protein, beta-1,4-GalT1 Protein, beta-1,4-galactosyltransferase 1 Protein, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 Protein, B4GALT1 Protein, B4galt1 Protein

Hintergrund:

Background: Beta1,4-Galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides. By sequence similarity, the beta 4GalTs form four groups: beta 4GalT1 and beta 4GalT2, beta 4GalT3 and beta 4GalT4, beta 4GalT5 and beta 4GalT6, and beta 4GalT7. beta 4GalT1 is unique among the seven enzymes because it can be expressed either as membrane associated form or secreted form. The secreted form is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha -lactalbumin to catalyze the synthesis of lactose. The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. Defects in beta 4GalT1 are the cause of congenital disorder of glycosylation type 2D (CDG2D) .

Synonym: 1,4- galactosyltransferase, polypeptide 1, B4GalT1, B4GAL-T1, beta-1,4-galactosyltransferase 1, Beta-1,4-GalTase 1, beta4Gal-T1, betaGlcNAc beta, CDG2D, GT1, GTB

Molekulargewicht: 40.1 kDa

UniProt: P15291

Pathways: Glycosaminoglycan Metabolic Process