UBE2L6 Protein (His tag)

Produktnummer ABIN7317347

Produktdetails

Target: UBE2L6 (Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses UBE2L6 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Ube2L6 Protein (His Tag)

Sequenz: Met 1-Ser 153

Produktmerkmale: A DNA sequence encoding the human UBE2L6 isoform 1 (O14933-1) (Met 1-Ser 153) was expressed, with a polyhistide tag at the N-terminus.

Reinheit: > 96 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 0.1 % Brij35, pH 8.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: UBE2L6 (Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6))

Andere Bezeichnung: Ube2L6 (UBE2L6 Produkte)

Synonyme: UBE2L6 Protein, RIG-B Protein, UBCH8 Protein, 2810489I21Rik Protein, Ubce8 Protein, Ubcm8 Protein, UbcM8 Protein, ubiquitin conjugating enzyme E2 L6 Protein, ubiquitin-conjugating enzyme E2L 6 Protein, UBE2L6 Protein, Ube2l6 Protein

Hintergrund:

Background: UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain. These domains accommodate the ATP-activated ubiquitin (Ub) or ubiquitin-like (UBL) protein via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the E1 and E3 enzymes and connect activation to covalent modification. By doing so, E2s differentiate effects on downstream substrates, either with a single Ub/UBL molecule or as a chain. UBCH8 is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. It catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. UBCH8 functions in the E6/E6-AP-induced ubiquitination of p53/TP53 and promotes ubiquitination and subsequent proteasomal degradation of FLT3. At protein level, it is present in natural killer cells.

Synonym: Ubiquitin/ISG15-Conjugating Enzyme E2 L6, Retinoic Acid-Induced Gene B Protein, RIG-B, UbcH8, Ubiquitin Carrier Protein L6, Ubiquitin-Protein Ligase L6, UBE2L6, UBCH8

Molekulargewicht: 19.6 kDa