Tryptophan Hydroxylase 1 Protein (TPH1) (His tag)

Produktnummer ABIN7317460

Produktdetails

Target: Tryptophan Hydroxylase 1 (TPH1)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Tryptophan Hydroxylase 1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag)

Sequenz: Ile 2-Ile 444

Produktmerkmale: A DNA sequence encoding the human TPH1 (P17752-1) (Ile 2-Ile 444) was expressed, with a polyhistide tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 200 mM NaCl, 10 % glycerol, pH 8.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Tryptophan Hydroxylase 1 (TPH1)

Andere Bezeichnung: Tryptophan Hydroxylase 1/TPH1 (TPH1 Produkte)

Synonyme: TPRH Protein, TRPH Protein, tph Protein, tph1 Protein, tphD1 Protein, tph2 Protein, tph1l Protein, tphD2 Protein, Tph Protein, TPH Protein, SERGEF Protein, LOC100229598 Protein, tryptophan hydroxylase 1 Protein, tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a Protein, TryPtophan Hydroxylase Protein, tryptophan hydroxylase 1b Protein, tryptophan hydroxylase 1 L homeolog Protein, tryptophan 5-hydroxylase 1 Protein, TPH1 Protein, tph1a Protein, tph-1 Protein, tph1b Protein, Tph1 Protein, tph1.L Protein, LOAG_02149 Protein, Tsp_05203 Protein

Hintergrund:

Background: Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme which belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.

Synonym: TPRH;TRPH

Molekulargewicht: 52.7 kDa

Pathways: Feeding Behaviour