TMED1 Protein (Fc Tag)

Produktnummer ABIN7317263

Produktdetails

Target: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses TMED1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human TMED1 Protein (Fc Tag)(Active)

Sequenz: Met 1-Asn194

Produktmerkmale: A DNA sequence encoding the human TMED1 (Q13445) (Met1-Asn194) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA.2.Immobilized mouse ST2-His at 10μg/mL (100μL/well) can bind human TMED1-Fc, the EC50 of human TMED1-Fc is 0.05-0.2μg/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Andere Bezeichnung: TMED1 (TMED1 Produkte)

Synonyme: Il1rl1l Protein, Ly84l Protein, St2l Protein, IL1RL1LG Protein, Tp24 Protein, tmed1 Protein, zgc:92038 Protein, zgc:158680 Protein, transmembrane p24 trafficking protein 1 Protein, transmembrane p24 trafficking protein 1a Protein, transmembrane p24 trafficking protein 1b Protein, Tmed1 Protein, TMED1 Protein, tmed1a Protein, tmed1b Protein

Hintergrund:

Background: TMED1 belongs to the EMP24/GP25L family. It contains 1 GOLD domain and is widely expressed. TMED1 binds to its receptor IL1RL1 and results in the activation of DNA binding by nuclear factor NF-kappa-B or transcription from the IL8 promoter and most likely requires other proteins to elicit these activities. Dendritic cells from Peyer's patches (but not from spleen) express TMED1 in response to treatment with LPS. TMED1 may play a role in vesicular protein trafficking, mainly in the early secretory pathway. It may act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.

Synonym: Il1rl1l,IL1RL1LG,Tp24

Molekulargewicht: 46.2 kDa

UniProt: Q13445