Transglutaminase 2 Protein (His tag)

Produktnummer ABIN7317657

Produktdetails

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses Transglutaminase 2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human TGM2/Transglutaminase 2 Protein (His Tag)

Sequenz: Met 1-Ala 687

Produktmerkmale: A DNA sequence encoding the human TGM2 (NP_004604.2) (Met 1-Ala 687) was expressed, with a polyhistidine tag at the N-terminus.

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 2 mM DTT, 10 % glycerol, pH 8.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Andere Bezeichnung: TGM2/Transglutaminase 2 (TGM2 Produkte)

Synonyme: G-ALPHA-h Protein, GNAH Protein, TG2 Protein, TGC Protein, tgm2 Protein, zgc:101081 Protein, TgaseII Protein, TGM2 Protein, fc12b04 Protein, wu:fc12b04 Protein, zgc:136700 Protein, TGL2 Protein, G[a]h Protein, TGase2 Protein, tTG Protein, tTGas Protein, transglutaminase 2 Protein, transglutaminase 2, C polypeptide A Protein, transglutaminase 2b Protein, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) Protein, transglutaminase 2, C polypeptide Protein, TGM2 Protein, tgm2a Protein, Tgm2 Protein, tgm2b Protein

Hintergrund:

Background: Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which catalyzes transamidation reactions or acts as a G-protein in intracellular signalling. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TGM2 is likely to play a modulatory role in nervous system development and has regulatory effect on neuronal cell death as well. Most importantly, numerous studies have presented data demonstrating that dysregulation of TGM2 may contribute to the pathogenesis of many neurodegenerative disorders, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis as well as nervous system injuries.

Synonym: G-ALPHA-h,GNAH,HEL-S-45,TG2,TGC

Molekulargewicht: 79.6 kDa

NCBI Accession: NP_004604

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling