TK1 Protein (His tag)

Produktnummer ABIN7319084

Produktdetails

Target: TK1 (Thymidine Kinase 1, Soluble (TK1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses TK1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human TK1 Protein (His Tag)

Sequenz: Met 1-Asn234

Produktmerkmale: Recombinant Human Thymidine kinase, Cytosolic is produced by our Mammalian expression system and the target gene encoding Met1-Asn234 is expressed with a 6His tag at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,150 mM NaCl,1 mM DTT,2 mM EDTA, 10 % Glycerol, pH 7.5.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: TK1 (Thymidine Kinase 1, Soluble (TK1))

Andere Bezeichnung: TK1 (TK1 Produkte)

Synonyme: fi19b06 Protein, zgc:55362 Protein, wu:fi19b06 Protein, TK1 Protein, tk2 Protein, D530002A18Rik Protein, Tk-1 Protein, Tk1a Protein, Tk1b Protein, TK2 Protein, Tk Protein, TK Protein, thymidine kinase 1, soluble Protein, thymidine kinase 1 Protein, thymidine kinase, cytosolic Protein, Thymidine kinase, cytosolic Protein, temporal expression: early Protein, thymidine kinase Protein, Tk thymidine kinase Protein, tk1 Protein, TK1 Protein, EDI_049980 Protein, kith Protein, J2R Protein, HVT031 Protein, Tk1 Protein, tk Protein

Hintergrund:

Background: Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm, and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this protein have been identified in animal cells, one in cytosol TK1 and one in mitochondria TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle, while it is very low in resting cells. TK1 acts as a homotetramer, and can transform thymidime to thymidine 5'-phosphate with the help of ATP

Synonym: Thymidine kinase, cytosolic,TK1

Molekulargewicht: 26.5 kDa

UniProt: P04183