Thymic Stromal Lymphopoietin Protein (TSLP) (His tag)

Produktnummer ABIN7198241

Produktdetails

Target: Thymic Stromal Lymphopoietin (TSLP)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Thymic Stromal Lymphopoietin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse TSLP Protein (His Tag)(Active)

Sequenz: Met 1-Glu 140

Produktmerkmale: A DNA sequence encoding the mouse TSLP (Q9JIE6) (Met 1-Glu 140) was expressed, with a C-terminal polyhistidine tag.

Reinheit: > 90 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind human IL7RA-his in functional ELISA.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Thymic Stromal Lymphopoietin (TSLP)

Andere Bezeichnung: TSLP (TSLP Produkte)

Synonyme: TSLP Protein, thymic stromal lymphopoietin Protein, TSLP Protein, Tslp Protein

Hintergrund:

Background: Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation.  Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.

Synonym: Thymic stromal lymphopoietin;Thymic stroma-derived lymphopoietin;Tslp;TSLP

Molekulargewicht: 15.4 kDa

UniProt: Q9JIE6