THSD1 Protein (His tag)

Produktnummer ABIN7320290

Produktdetails

Target: THSD1 (Thrombospondin, Type I, Domain Containing 1 (THSD1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses THSD1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse THSD1/TMTSP Protein (His Tag)

Sequenz: Met 1-Asn 412

Produktmerkmale: A DNA sequence encoding the extracellular domain of mouse THSD1 (NP_062522.1) (Met 1-Asn 412) was expressed, with a C-terminal polyhistidine tag.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: THSD1 (Thrombospondin, Type I, Domain Containing 1 (THSD1))

Andere Bezeichnung: THSD1/TMTSP (THSD1 Produkte)

Synonyme: 4833423O18Rik Protein, Tmtsp Protein, TMTSP Protein, UNQ3010 Protein, thrombospondin, type I, domain 1 Protein, thrombospondin type 1 domain containing 1 Protein, Thsd1 Protein, THSD1 Protein

Hintergrund:

Background: Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein which contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types.

Synonym: 4833423O18Rik,Tmtsp

Molekulargewicht: 45 kDa

NCBI Accession: NP_062522