SDC4 Protein (Fc Tag)

Produktnummer ABIN7320171

Produktdetails

Target: SDC4 (Syndecan 4 (SDC4))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SDC4 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Mouse Syndecan-4/SDC4 Protein (Fc Tag)(Active)

Sequenz: Met1-Val146

Produktmerkmale: A DNA sequence encoding the mouse SDC4 (O35988)(Met1-Val146) was expressed with the Fc region of human IgG1 at the C-terminus.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized human MDK at 10 μg/ml (100 μl/well) can bind mouse SDC4-Fc with a linear range of 0.16-1.25 μg/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SDC4 (Syndecan 4 (SDC4))

Andere Bezeichnung: Syndecan-4/SDC4 (SDC4 Produkte)

Synonyme: SYND4 Protein, AA959608 Protein, AW108331 Protein, Synd4 Protein, ryudocan Protein, syndecan-4 Protein, RATRYUDOCA Protein, RYUDOCA Protein, SDC4 Protein, sdc4l Protein, wu:fc47g09 Protein, Syndecan-4 Protein, amphiglycan Protein, syn-4 Protein, syn4 Protein, syndecan 4 Protein, syndecan 4 S homeolog Protein, syndecan 4 L homeolog Protein, SDC4 Protein, Sdc4 Protein, sdc4 Protein, sdc4.S Protein, sdc4.L Protein

Hintergrund:

Background: SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.

Synonym: AA959608,AW108331,ryudocan,Synd4,syndecan-4,SDC4,SYND4,Ryudocan core protein

Molekulargewicht: 40.5 kDa

UniProt: O35988

Pathways: Glycosaminoglycan Metabolic Process