SFTPD Protein (His tag)

Produktnummer ABIN7320367

Produktdetails

Target: SFTPD (Surfactant Protein D (SFTPD))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SFTPD Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse SFTPD/SP-D Protein (His Tag)

Sequenz: Met 1-Phe 374

Produktmerkmale: A DNA sequence encoding the mouse SFTPD (NP_033186.1) precursor (Met 1-Phe 374) was expressed with a C-terminal polyhistidine tag.

Reinheit: > 97 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SFTPD (Surfactant Protein D (SFTPD))

Andere Bezeichnung: SFTPD/SP-D (SFTPD Produkte)

Synonyme: COLEC7 Protein, PSP-D Protein, SFTP4 Protein, SP-D Protein, BDE Protein, BDSD Protein, HOX4I Protein, SPD Protein, AI573415 Protein, Sftp4 Protein, surfactant protein D Protein, homeobox D13 Protein, surfactant associated protein D Protein, SFTPD Protein, HOXD13 Protein, Sftpd Protein, SP-D Protein

Hintergrund:

Background: Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia and asthma. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.

Synonym: COLEC7, Collectin 7, Lung surfactant protein D, PSPD, Pulmonary surfactant-associated protein D, SFTPD, SPD, SP-D, SP-Dpulmonary surfactant apoprotein, surfactant protein D, surfactant, pulmonary-associated protein D,SFTP4

Molekulargewicht: 37.2 kDa

NCBI Accession: NP_033186