SOD1 Protein (His tag)

Produktnummer ABIN7317500

Produktdetails

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses SOD1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human SOD1/Superoxide Dismutase 1 Protein (His Tag)

Sequenz: Ala 2-Gln 154

Produktmerkmale: A DNA sequence encoding the human SOD1 (NP_000445.1) (Ala 2-Gln 154) was expressed, with a polyhistide tag at the N-terminus.

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Andere Bezeichnung: SOD1/Superoxide Dismutase 1 (SOD1 Produkte)

Synonyme: LOC692639 Protein, ALS Protein, ALS1 Protein, IPOA Protein, SOD Protein, hSod1 Protein, homodimer Protein, CG11793 Protein, Cu Protein, Cu-Zn SOD Protein, Cu/Zn SOD Protein, Cu/Zn sod Protein, Cu/Zn superoxide dismutase Protein, Cu/ZnSOD Protein, CuSOD Protein, CuZn SOD Protein, CuZn-SOD Protein, CuZn-SOD1 Protein, CuZnSOD Protein, Cu[2+]/Zn[2+]SOD Protein, Dmel\\CG11793 Protein, G Protein, Mn SOD Protein, SOD-1 Protein, SOD1 Protein, Sod-1 Protein, Sod1 Protein, To Protein, To-1 Protein, Zn SOD Protein, Zn Sod Protein, Zn-SOD Protein, ZnSod Protein, cSOD Protein, cSod Protein, dSOD1 Protein, l(3)108 Protein, l(3)68Af' Protein, l(3)G Protein, sod Protein, sod1 Protein, CU/ZN-SOD Protein, SODC Protein, DKFZP469M1833 Protein, B430204E11Rik Protein, Cu/Zn-SOD Protein, Ipo-1 Protein, Ipo1 Protein, SOD1L1 Protein, XSODB Protein, als Protein, als1 Protein, ipoa Protein, sod1-a Protein, ZSOD Protein, cuzn Protein, Cu/Zn superoxide dismutase Protein, superoxide dismutase 1 Protein, Superoxide dismutase 1 Protein, superoxide dismutase 1, soluble Protein, superoxide dismutase 1 S homeolog Protein, Superoxide dismutase [Cu-Zn] Protein, superoxide dismutase 1 L homeolog Protein, superoxide dismutase [Cu-Zn]-like Protein, superoxide dismutase [Cu-Zn] Protein, superoxide dismutase Sod1 Protein, SOD Protein, SOD1 Protein, Sod1 Protein, sod1 Protein, sod1.S Protein, sod-1 Protein, sod1.L Protein, LOC101451855 Protein, LOC101115136 Protein

Hintergrund:

Background: SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. SOD1 destroys radicals which are normally produced within the cells and which are toxic to biological systems. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1). ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10 % of cases leading to familial forms.

Synonym: Superoxide Dismutase [Cu-Zn], Superoxide Dismutase 1, hSod1,ALS,ALS1,HEL-S-44,homodimer,hSod1,IPOA

Molekulargewicht: 16.8 kDa

NCBI Accession: NP_000445

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis