SPG21 Protein (GST tag,His tag)

Produktnummer ABIN7320147

Produktdetails

Target: SPG21 (Spastic Paraplegia 21 (SPG21))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses SPG21 Protein ist gelabelt mit GST tag,His tag.

Verwendungszweck: Recombinant Mouse SPG21 Protein (His & GST Tag)

Sequenz: Met 1-Pro 308

Produktmerkmale: A DNA sequence encoding the mouse SPG21 isoform 1 (Q9CQC8-1) (Met 1-Pro 308) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Reinheit: > 90 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 3 mM DTT, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SPG21 (Spastic Paraplegia 21 (SPG21))

Andere Bezeichnung: SPG21 (SPG21 Produkte)

Synonyme: ACP33 Protein, GL010 Protein, MAST Protein, BM-019 Protein, C78576 Protein, D9Wsu18e Protein, Maspardin Protein, wu:fd07h02 Protein, zgc:73091 Protein, SPG21, maspardin Protein, spastic paraplegia 21 (autosomal recessive, Mast syndrome) Protein, SPG21, maspardin S homeolog Protein, SPG21 Protein, Spg21 Protein, spg21.S Protein, spg21 Protein

Hintergrund:

Background: Spastic paraplegia 21 (SPG21), also known as acid Cluster Protein 33 (ACP33) and Mast syndrome protein, is a member of the AB hydrolase superfamily. Human SPG21 is a 308 amino acid residue protein widely expressed in all tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. SPG21 binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation via the noncatalytic alpha/beta hydrolase fold domain. SPG21 thus is proposed to play a role as a negative regulatory factor in CD4-dependent T-cell activation of CD4. Defects in SPG21 are the cause of spastic paraplegia autosomal recessive type 21, also known as Mast syndrome, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. SPG21 is also associated with dementia and other central nervous system abnormalities.

Synonym: ACP33,BM-019,C78576,D9Wsu18e,GL010,MAST

Molekulargewicht: 62.8kDa