SLITRK1 Protein (His tag,Fc Tag)

Produktnummer ABIN7317905

Produktdetails

Target: SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SLITRK1 Protein ist gelabelt mit His tag,Fc Tag.

Verwendungszweck: Recombinant Human SLITRK1 Protein (His & Fc Tag)

Sequenz: Met 1-Ser 616

Produktmerkmale: A DNA sequence encoding the extracellular domain (Met 1-Ser 616) of human SLITRK1 (NP_443142.1) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))

Andere Bezeichnung: SLITRK1 (SLITRK1 Produkte)

Synonyme: DKFZp459G0529 Protein, LRRC12 Protein, TTM Protein, 3200001I04Rik Protein, SLIT and NTRK like family member 1 Protein, SLIT and NTRK-like family, member 1 Protein, SLITRK1 Protein, slitrk1 Protein, Slitrk1 Protein

Hintergrund:

Background: SLITRK1 (Slit and Trk-like family member 1) is a integral membrane protein belonging to the SLITRK family consists of at least 6 members (SLITRK1-6). They are named and characterized by the presence of two leucine-rich repeats (LRRs) in the extracellular domain similar to those found in a secreted axonal growth-controlling protein, Slit, as well as a C-terminal domain with homology to Trk neurotrophin tyrosine kinase receptors. Expression of SLITRKs are highly restricted to neural tissues, and are identified as the neuronal components modulating the neurite outgrowth. More specifically, SLITRK1 expression is found in the mature neurons of the cerebrum, thalamus and hippocampus, and induces unipolar neurites in cultured neuronal cells. Human SLITRK1 is a 696 amino acid precursor protein, and one truncating frameshift mutation (448 aa) has been linked to Tourette's syndrome, a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. In addition, all SLITRK genes are differentially expressed in brain tumors, such as astrocytoma, oligodendroglioma, glioblastoma, and are suggested to be useful molecular indicators of brain tumor properties.

Synonym: FLJ54428,KIAA0918,KIAA1910,LRRC12,RP11-395N17.1,SLITRK1,TTM

Molekulargewicht: 95 kDa

NCBI Accession: NP_443142