SERPINB1 Protein (His tag)

Produktnummer ABIN7318726

Produktdetails

Target: SERPINB1 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1 (SERPINB1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses SERPINB1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human SERPINB1/PI2 Protein (Human Cells, His Tag)

Sequenz: Met 1-Pro379

Produktmerkmale: Recombinant Human Serine Protease Inhibitor-clade B1 is produced by our Mammalian expression system and the target gene encoding Met1-Pro379 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SERPINB1 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1 (SERPINB1))

Andere Bezeichnung: SERPINB1/PI2 (SERPINB1 Produkte)

Synonyme: ELANH2 Protein, zgc:91981 Protein, si:dkey-177p2.11 Protein, si:dkey-177p2.12 Protein, EI Protein, LEI Protein, M/NEI Protein, MNEI Protein, PI-2 Protein, PI2 Protein, elanh2 Protein, lei Protein, m/nei Protein, mnei Protein, pi2 Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 1 Protein, serpin family B member 1 Protein, serpin family B member 1 L homeolog Protein, SERPINB1 Protein, serpinb1 Protein, serpinb1.L Protein

Hintergrund:

Background: SERPINB1 is a member of the serpin family and Ov-serpin subfamily. As protease inhibitors, serpins have an array of functions including regulating blood coagulation, fibrinolysis, the complement pathway, angiogenesis, inflammation, tumor suppression, extracellular matrix remodeling, and cell motility. SERPINB1 regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Reactive bond 1 of SerpinB1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin or chymase. Reactive bond 2 of SerpinB1 is specific for reaction with elastase-like protease such as neutrophyl elastase, proteinase-3, pancreatic elastase or PSA. In addition, SERPINB1 also functions as a potent intracellular inhibitor of granzyme H.

Synonym: Leukocyte elastase inhibitor,SERPINB1, Monocyte/neutrophil elastase inhibitor, M/NEI, Peptidase inhibitor 2, PI-2, PI2, EI,ELANH2,HEL-S-27,HEL57,LEI,MNEI,

Molekulargewicht: 43.8 kDa

UniProt: P30740