SPINT2 Protein (His tag)

Produktnummer ABIN7197930

Produktdetails

Target: SPINT2 (serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SPINT2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse HAI-2/SPINT2 Protein (His Tag)

Sequenz: Met 1-Lys 140

Produktmerkmale: A DNA sequence encoding the extracellular domain (Met 1-Lys 140) of mouse SPINT2 (NP_001076017.1) precursor was expressed with a C-terminal polyhistidine tag.

Reinheit: > 90 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SPINT2 (serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))

Andere Bezeichnung: HAI-2/SPINT2 (SPINT2 Produkte)

Synonyme: HAI-2 Protein, Pb Protein, DIAR3 Protein, HAI2 Protein, Kop Protein, PB Protein, AL024025 Protein, C76321 Protein, serine peptidase inhibitor, Kunitz type, 2 Protein, serine peptidase inhibitor, Kunitz type 2 Protein, serine protease inhibitor, Kunitz type 2 Protein, Spint2 Protein, SPINT2 Protein

Hintergrund:

Background: Choanal (CA) and gastrointestinal atresias (GA) are an important feature of syndromic congenital sodium diarrhea (sCSD), a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 (SPINT2). The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression. SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation. SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), which has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression.

Synonym: AL024025,C76321,HAI-2

Molekulargewicht: 14 kDa

NCBI Accession: NP_001076017