S100A7 Protein

Produktnummer ABIN7319482

Produktdetails

Target: S100A7 (S100 Calcium Binding Protein A7 (S100A7))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Verwendungszweck: Recombinant Human S100A7/PSOR1 Protein

Sequenz: Met1-Gln101

Produktmerkmale: Recombinant Human S100A7 is produced by our E.coli expression system and the target gene encoding Met1-Gln101 is expressed.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: S100A7 (S100 Calcium Binding Protein A7 (S100A7))

Andere Bezeichnung: S100A7/PSOR1 (S100A7 Produkte)

Synonyme: PSOR1 Protein, S100A7c Protein, S100A7 Protein, S100 calcium binding protein A7 Protein, protein S100-A7 Protein, S100A7 Protein, LOC469501 Protein, LOC713189 Protein, LOC714943 Protein, LOC101104285 Protein, LOC102191570 Protein

Hintergrund:

Background: S100A7 is a 11-12 kDa member of the S100 family of EF hand calcium binding proteins. Human S100A7 shares 32 % amino acid sequence identity with mouse S100A7A, the closest related protein in mouse. It is acetylated at the N-terminus and binds both calcium and zinc ions. S100A7 is up-regulated in keratinocytes of psoriasis and atopic dermatitis lesions, as well as in epithelial cells of the tongue, eye, and female genital tract. Its up-regulation can be induced by bacterial exposure, inflammatory cytokines, or epidermal barrier disruption. S100A7 supports epithelial integrity through killing E. coli by sequestration of zinc and through inducing the up-regulation of tight junction proteins. The interaction of S100A7 with RAGE promotes the migration of immune cells and the infiltration of macrophages into tumor sites.

Synonym: Protein S100-A7, Psoriasin, S100 calcium-binding protein A7, S100A7, PSOR1, S100A7C

Molekulargewicht: 11.5 kDa

UniProt: P31151

Pathways: S100 Proteine