PRSS3 Protein (His tag)

Produktnummer ABIN7197546

Produktdetails

Target: PRSS3 (Protease, serine, 3 (PRSS3))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PRSS3 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Trypsin-3/PRSS3 Protein (His Tag)(Active)

Sequenz: Met 1-Ser 247

Produktmerkmale: A DNA sequence encoding the human PRSS3 isoform c (P35030-3) (Met 1-Ser 247) was expressed, with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (AnaSpec, Catalog#27114). The specific activity is >4,000 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by enteropeptidase for an activated form)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM MES, 0.6M NaCl, pH 5.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PRSS3 (Protease, serine, 3 (PRSS3))

Andere Bezeichnung: Trypsin-3/PRSS3 (PRSS3 Produkte)

Synonyme: MTG Protein, PRSS4 Protein, T9 Protein, TRY3 Protein, TRY4 Protein, Try3 Protein, Tb Protein, prss3 Protein, protease, serine 3 Protein, trypsin-3 Protein, protease, serine, 3 Protein, trypsin III Protein, protease, serine 3 L homeolog Protein, PRSS3 Protein, CpipJ_CPIJ016105 Protein, Prss3 Protein, trp-iii Protein, prss3.L Protein

Hintergrund:

Background: Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein which belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.

Synonym: MTG;PRSS4;RP11-176F3.3;T9;TRY3;TRY4

Molekulargewicht: 26.6 kDa