PRSS27 Protein (His tag)

Produktnummer ABIN7197543

Produktdetails

Target: PRSS27 (Protease, Serine 27 (PRSS27))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PRSS27 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Pancreasin/Marapsin/PRSS27 Protein (His Tag)(Active)

Sequenz: Met 1-Lys 290

Produktmerkmale: A DNA sequence encoding the human PRSS27 (Q9BQR3) extracellular domain (Met 1-Lys 290) was expressed, fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave a colorimetric peptide substrate, NcarbobenzyloxyGlyArgThioBenzyl ester (ZGR-SBzl), in the presence of 5,5'Dithiobis (2-nitrobenzoic acid) (DTNB).The specific activity is > 2000 pmols/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PRSS27 (Protease, Serine 27 (PRSS27))

Andere Bezeichnung: Pancreasin/Marapsin/PRSS27 (PRSS27 Produkte)

Synonyme: PRSS27 Protein, mpn Protein, caph2 Protein, tmprss9 Protein, marapsin Protein, pancreasin Protein, MGC97879 Protein, CAPH2 Protein, MPN Protein, Mpn Protein, protease, serine 27 Protein, epidermis specific serine protease S homeolog Protein, PRSS27 Protein, prss27 Protein, xepsin.S Protein, Prss27 Protein

Hintergrund:

Background: The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), which is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most strongly up-regulated protease in psoriatic lesions, where expression was localized to the upper region of the hyperplastic epidermis. Similarly, in the hyperproliferative epithelium of regenerating murine skin wounds, marapsin localized to the suprabasal layers, where keratinocytes undergo squamous differentiation. Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.

Synonym: CAPH2;MPN;UNQ1884/PRO4327

Molekulargewicht: 30.9 kDa

UniProt: Q9BQR3