PDE3A Protein (GST tag,His tag)

Produktnummer ABIN7317464

Produktdetails

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses PDE3A Protein ist gelabelt mit GST tag,His tag.

Verwendungszweck: Recombinant Human PDE3A Protein (His & GST Tag)

Sequenz: Lys669-Gln1141

Produktmerkmale: A DNA sequence encoding the human PDE3A (Q14432) (Lys669-Gln1141) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 3 mM DTT

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Andere Bezeichnung: PDE3A (PDE3A Produkte)

Synonyme: PDE3A Protein, Pde3a Protein, si:dkey-48h7.2 Protein, A930022O17Rik Protein, C87899 Protein, RNPDE3A Protein, CGI-PDE Protein, CGI-PDE A Protein, CGI-PDE-A Protein, phosphodiesterase 3A Protein, phosphodiesterase 3A, cGMP-inhibited Protein, cGMP-inhibited 3',5'-cyclic phosphodiesterase A Protein, phosphodiesterase 3A, cGMP inhibited Protein, PDE3A Protein, Pde3a Protein, LOC100540515 Protein, pde3a Protein

Hintergrund:

Background: PDE3A belongs to the phosphodiesterase family. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory. PDE3A has high affinity for both cAMP and cGMP and shows competitive inhibition of the cAMP hydrolytic activity by cGMP. It plays a critical role in regulating intracellular levels of cAMP and cGMP.

Synonym: CGI-PDE,CGI-PDE-A,CGI-PDEA

Molekulargewicht: 81.7 kDa

UniProt: Q14432

Pathways: cAMP Metabolic Process