PIP4K2A Protein (His tag)

Produktnummer ABIN7318894

Produktdetails

Target: PIP4K2A (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, alpha (PIP4K2A))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses PIP4K2A Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human PIP4K2A Protein (His Tag)

Sequenz: Met 1-Thr406

Produktmerkmale: Recombinant Human Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha is produced by our Mammalian expression system and the target gene encoding Met1-Thr406 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PIP4K2A (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, alpha (PIP4K2A))

Andere Bezeichnung: PIP4K2A (PIP4K2A Produkte)

Synonyme: PI5P4KA Protein, PIP5K2A Protein, PIP5KII-alpha Protein, PIP5KIIA Protein, PIPK Protein, AW742916 Protein, Pip5k2a Protein, pipk Protein, pi5p4ka Protein, pip5k2a Protein, pip5kiia Protein, pip4k2a Protein, zgc:194746 Protein, zgc:194777 Protein, phosphatidylinositol-5-phosphate 4-kinase type 2 alpha Protein, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Protein, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha S homeolog Protein, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a Protein, PIP4K2A Protein, Pip4k2a Protein, pip4k2a.S Protein, pip4k2a Protein, pip4k2aa Protein

Hintergrund:

Background: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

Synonym: 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha,Diphosphoinositide kinase 2-alpha,PIP5KIII,Phosphatidylinositol 5-phosphate 4-kinase type II alpha,PtdIns(4)P-5-kinase B isoform,PtdIns(4)P-5-kinase C isoform,PtdIns(5)P-4-kinase isoform 2-alpha

Molekulargewicht: 47.3 kDa

UniProt: P48426

Pathways: Inositol Metabolic Process