KIAA0101 Protein (His tag)

Produktnummer ABIN7317700

Produktdetails

Target: KIAA0101 (PAF) (PCNA Clamp Associated Factor (PAF))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses KIAA0101 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human KIAA0101/p15/PAF Protein (His Tag)

Sequenz: Met 1-Glu 111

Produktmerkmale: A DNA sequence encoding the human PAF isoform 1 (NP_055551.1) (Met 1-Glu 111) was expressed, with a polyhistide tag at the N-terminus.

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: KIAA0101 (PAF) (PCNA Clamp Associated Factor (PAF))

Andere Bezeichnung: KIAA0101/p15/PAF (PAF Produkte)

Synonyme: NS5ATP9 Protein, OEATC Protein, OEATC-1 Protein, OEATC1 Protein, PAF Protein, PAF15 Protein, p15(PAF) Protein, p15/PAF Protein, p15PAF Protein, paf Protein, Paf Protein, AA409629 Protein, Ns5apt9 Protein, Ns5atp9 Protein, mKIAA0101 Protein, Kiaa0101 Protein, PCNA clamp associated factor Protein, PCNA clamp associated factor S homeolog Protein, PCLAF Protein, pclaf Protein, pclaf.S Protein, Pclaf Protein

Hintergrund:

Background: KIAA0101, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor which interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners, and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA0101 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21 . KIAA0101 is involved in cell proliferation and plays a role in early tumor recurrence (ETR), and prognosis of hepatocellular carcinoma (HCC). KIAA0101 is expressed predominantly in liver, pancreas and placenta. It cannot be detected in heart or brain. It is highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas and in non-small-cell lung cancer lines. Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma. It also may be involved in protection of cells from UV-induced cell death.

Synonym: KIAA0101,L5,NS5ATP9,OEATC,OEATC-1,OEATC1,p15(PAF),p15/PAF,p15PAF,PAF,PAF15

Molekulargewicht: 13.8 kDa

NCBI Accession: NP_055551

Pathways: Chromatin Binding