OMG Protein (AA 1-245) (His tag)

Produktnummer ABIN7320193

Produktdetails

Target: OMG (Oligodendrocyte Myelin Glycoprotein (OMG))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-245

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses OMG Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse OMGP/OMG Protein (aa 1-245, His Tag)

Sequenz: Met 1-Thr 245

Produktmerkmale: A DNA sequence encoding the amino acids (Met 1-Thr 245) of mouse OMGP (Q63912) was expressed, with a C-terminal polyhistidine tag.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: OMG (Oligodendrocyte Myelin Glycoprotein (OMG))

Andere Bezeichnung: OMGP/OMG (OMG Produkte)

Synonyme: OMGP Protein, omgp Protein, MGC107958 Protein, OMG Protein, DKFZp459F1351 Protein, oligodendrocyte myelin glycoprotein Protein, myelin oligodendrocyte glycoprotein Protein, oligodendrocyte-myelin glycoprotein Protein, OMG Protein, MOG Protein, Omg Protein, omg Protein

Hintergrund:

Background: Oligodendrocyte-myelin glycoprotein, also known as OMG and OMGP, is a cell membrane protein which contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR, the receptor for Nogo. This function requires its leucine-rich repeat domain, a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation, neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.

Synonym: RP23-67E18.6, LNGFR, Tnfrsf16, p75, p75NGFR, p75NTR

Molekulargewicht: 27 kDa

UniProt: Q63912

Pathways: Neurotrophin Signalübertragung, Regulation of Cell Size