NPC1 Protein (His tag,DYKDDDDK Tag)

Produktnummer ABIN7317151

Produktdetails

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NPC1 Protein ist gelabelt mit His tag,DYKDDDDK Tag.

Verwendungszweck: Recombinant Human NPC1 Protein (His & FLAG Tag)

Sequenz: Arg372-Phe622

Produktmerkmale: A DNA sequence encoding the human NPC1 (NP_000262.2) (Arg372-Phe622) was expressed with a N-terminal polyhistide-tagged FLAG tag at the N-terminus (his-FLAG).

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Andere Bezeichnung: NPC1 (NPC1 Produkte)

Synonyme: NPC Protein, 9130221N23Rik Protein, Gm243 Protein, Cdig2 Protein, im:7149020 Protein, wu:fb53a12 Protein, wu:fc29a12 Protein, A430089E03Rik Protein, C85354 Protein, D18Ertd139e Protein, D18Ertd723e Protein, lcsd Protein, nmf164 Protein, spm Protein, NPC intracellular cholesterol transporter 1 Protein, NPC1 like intracellular cholesterol transporter 1 Protein, Niemann-Pick disease, type C1 Protein, Niemann-Pick C1 protein Protein, NPC1 Protein, Npc1l1 Protein, Npc1 Protein, npc1 Protein, LOC579887 Protein

Hintergrund:

Background: Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL.The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick type C1. NPC1 localizes predominantly to late endosomes and has a dileucine motif located within a small cytoplasmic tail thought to target the protein to this location.Niemann-Pick disease Type C1 (NPC1) is a rare progressive neurodegenerative disorder caused by mutations in the NPC1 gene. On the cellular level NPC1 mutations lead to an accumulation of cholesterol and gangliosides.

Synonym: NPC

Molekulargewicht: 32 kDa

NCBI Accession: NP_000262