NMNAT2 Protein (His tag)

Produktnummer ABIN7197199

Produktdetails

Target: NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses NMNAT2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human NMNAT2/NMNAT-2 Protein (His Tag)

Sequenz: Met 1-Gly307

Produktmerkmale: A DNA sequence encoding the human NMNAT2 (Q9BZQ4-1)(Met1-Gly307) was fused with a polyhistide tag at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 5 mM DTT, 10 % glycerol, pH 8.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))

Andere Bezeichnung: NMNAT2/NMNAT-2 (NMNAT2 Produkte)

Synonyme: zgc:73048 Protein, wu:fj59g01 Protein, NMNAT2 Protein, C1orf15 Protein, PNAT2 Protein, AI843915 Protein, D030041I09Rik Protein, PNAT1 Protein, nicotinamide nucleotide adenylyltransferase 2 Protein, nmnat2 Protein, NMNAT2 Protein, Nmnat2 Protein

Hintergrund:

Background: NMNAT2, also known as NMNAT-2, belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family. NMNAT is a central enzyme in NAD+ biosynthesis, transferring the adenylyl moiety of ATP to nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) resulting in the formation of NAD+ or NaAD+ and the release of pyrophosphate. NMNAT2 is predominantly expressed in human pancreas, insulinoma as well as in the brain, especially in the cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Immunofluorescence microscopy localized endogenous NMNAT2 to the Golgi apparatus in human cell line. Endogenous NMNAT2 seem to be a labile axon survival factor, because specific depletion of NMNAT2 is sufficient to induce Wallerian-like degeneration of uninjured axons which endogenous NMNAT1 and NMNAT3 cannot prevent. Thus endogenous NMNAT2 represents an exciting new therapeutic target for axonal disorders.

Synonym: C1orf15,PNAT2

Molekulargewicht: 35.8 kDa