NEGR1 Protein (His tag)

Produktnummer ABIN7320220

Produktdetails

Target: NEGR1 (Neuronal Growth Regulator 1 (NEGR1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NEGR1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse NEGR1 Protein (His Tag)

Sequenz: Met 1-Gly 318

Produktmerkmale: A DNA sequence encoding the mouse NEGR1 (NP_001034183.1) (Met 1-Gly 318) without the pro peptide was expressed, with a C-terminal polyhistidine tag.

Reinheit: > 94 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NEGR1 (Neuronal Growth Regulator 1 (NEGR1))

Andere Bezeichnung: NEGR1 (NEGR1 Produkte)

Synonyme: zgc:100871 Protein, NEGR1 Protein, Ntra Protein, kilon Protein, DMML2433 Protein, IGLON4 Protein, KILON Protein, 5330422G01Rik Protein, mKIAA3001 Protein, NTRA-L Protein, NTRA-S Protein, neuronal growth regulator 1 Protein, neuronal growth regulator 1 L homeolog Protein, negr1 Protein, NEGR1 Protein, negr1.L Protein, Negr1 Protein

Hintergrund:

Background: Neuronal Growth Regulator 1, NEGR1, also known as neurotractin, or KILON, which belongs to the immunoglobulin superfamily, IgLON family. This GPI-linked cell surface glycoprotein NEGR1 is composed of three Ig-like domains and belongs to the IgLON subgroup of neural IgSF members. It is expressed in two isoforms with apparent molecular masses of 50 and 37 kD, termed L-form and S-form, respectively. NEGR1/Neurotractin participates in the regulation of neurite outgrowth in the developing brain, and is expressed on neurites of primary hippocampal neurons. Neurotractin/KILON is a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation. KILON (kindred of IgLON) and opioid-binding cell adhesion molecule belong to the IgLON subgroup of immunoglobulin superfamily together with the limbic system-associated membrane protein and neurotrimin. The alteration of modulatory function of KILON/NEGR1 for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development. In addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.

Synonym: 5330422G01Rik,KILON,Ntra

Molekulargewicht: 33 kDa

NCBI Accession: NP_001034183

Pathways: Feeding Behaviour