NCK1 Protein (His tag)

Produktnummer ABIN7318390

Produktdetails

Target: NCK1 (NCK Adaptor Protein 1 (NCK1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses NCK1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human NCK1 Protein (His Tag)

Sequenz: Met 1-Ser377

Produktmerkmale: Recombinant Human Non-catalytic Region of Tyrosine Kinase Adaptor Protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser377 is expressed with a 6His tag at the N-terminus.

Reinheit: > 80 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, 5 % Mannitol, pH 8.0.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NCK1 (NCK Adaptor Protein 1 (NCK1))

Andere Bezeichnung: NCK1 (NCK1 Produkte)

Synonyme: NCK Protein, NCKalpha Protein, nck-1 Protein, NCK1 Protein, 6330586M15Rik Protein, D230010O13Rik Protein, Nck Protein, Nck-1 Protein, Nck1 Protein, nck Protein, nck1-a Protein, nck1-b Protein, nckalpha Protein, NCK adaptor protein 1 Protein, non-catalytic region of tyrosine kinase adaptor protein 1 Protein, NCK adaptor protein 1b Protein, NCK adaptor protein 1 L homeolog Protein, NCK1 Protein, Nck1 Protein, nck1b Protein, nck1.L Protein

Hintergrund:

Background: Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing signals from receptor tyrosine kinases to downstream signal recipients, such as ELK1-dependent transcriptional activation in response to activated Ras signaling.

Synonym: Cytoplasmic Protein NCK1, NCK adaptor Protein 1, Nck-1, SH2/SH3 Adaptor Protein NCK-Alpha, NCK1, NCK

Molekulargewicht: 45.0 kDa

UniProt: P16333

Pathways: T-Zell Rezeptor Signalweg, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals